Presenilin 1 Deficiency Alters the Activity of Voltage-Gated Ca Channels in Cultured Cortical Neurons
نویسندگان
چکیده
David G. Cook, Xiaofan Li, Sheree D. Cherry, and Angela R. Cantrell Veterans Affairs Puget Sound Health Care System, Geriatric Research Education and Clinical Center (GRECC), Seattle, Washington; Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington School of Medicine, Seattle Washington; and Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis Tennessee
منابع مشابه
Presenilin 1 deficiency alters the activity of voltage-gated Ca2+ channels in cultured cortical neurons.
Presenilins 1 and 2 (PS1 and PS2, respectively) play a critical role in mediating gamma-secretase cleavage of the amyloid precursor protein (APP). Numerous mutations in the presenilins are known to cause early-onset familial Alzheimer's disease (FAD). In addition, it is well established that PS1 deficiency leads to altered intracellular Ca(2+) homeostasis involving endoplasmic reticulum Ca(2+) ...
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The roles of cyclic nucleotide-gated (CNG) channels in sensory transduction have long been recognized. More recent studies found that CNG channels are distributed in multiple brain regions involved in memory and learning, including the cortex, hippocampus and cerebellum. These findings suggest that their functions are not limited to sensory perception, but also to neuronal plasticity phenomena,...
متن کاملAn inward current induced by a putative cyclic nucleotide-gated channel in rat cerebellar Purkinje neurons
The roles of cyclic nucleotide-gated (CNG) channels in sensory transduction have long been recognized. More recent studies found that CNG channels are distributed in multiple brain regions involved in memory and learning, including the cortex, hippocampus and cerebellum. These findings suggest that their functions are not limited to sensory perception, but also to neuronal plasticity phenomena,...
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تاریخ انتشار 2005